Valor pronóstico de los factores clinicopatológicos Ki67, ciclina D1, ciclina D3 y CDK4 en el carcinoma gástrico / Pronostic value of clinicopathologic factors Ki67, cyclin D1, cyclin D3 and CDK4 in gastric carcinoma

- Propósito: Conocer el valor pronóstico de la ciclina Dl, ciclina D3, cdk4 y Ki67, estudiados por métodos inmunohistoquímicos, junto con las características clinicopatológicos de los carcinomas gástricos.- Métodos y resultados: Realizamos estudio inmunohistoquimicos de material incluido en parafina para ciclina D1, ciclina D3, cdk4 y Ki67 en 74 pacientes con carcinoma gástrico. Las inmunotinciones para ciclinas D1, D3 y cdk4 así el índice de proliferación de Ki67, el grado histológico y el tipo histológico (según la clasificación de Lauren) se compararon con la supervivencia. El 97 por ciento de los casos eran Ki67 positivos, el 29 por ciento para ciclina D1, el 23 por ciento para ciclina D3 y el 35 por ciento para cdk4. El análisis multivariante sólo mostró correlación entre el Ki67 (PI) (p<0,01) y la supervivencia. En el análisis univariante el grado histológico también se correlaciona con la supervivencia (p<0,03). La expresión de ciclina D3 se relaciona con cdk4 (p<0,001) y Ki67 (PI) (p<0,02) y la expresión de ciclina D1 con el grado histológico (p<0,03).- Conclusiones: Nuestros resultados sugieren que un índice de proliferación elevado de Ki67 y el grado histológico son marcadores de mal pronóstico. La sobreexpresión de la ciclina D1 podría tener un importante papel en la proliferación celular. La relación entre ciclina D3, cdk4 y Ki67 podrían explicarse por su papel a lo largo del ciclo celular. (AU)

[Urologic disease emergency. Clinico-epidemiologic analysis at a district hospital]. / Patología urológica urgente. Análisis clínico-epidemiológico en un hospital comarcal.

OBJECTIVE: To present the results of a one-year retrospective study that analyzed the clinical and epidemiological aspects of urological emergencies, which is not a negligible percentage of all hospital emergencies. METHODS: Data on all the urological emergencies of the emergency department of our hospital were collected during a one-year period by filling out a form that included sex, age, whether referred or not, disease, etc. RESULTS: There were 1504 urological emergencies; the urologist was required in 458 of these cases (30.45%). There were more men (837) than women (667). Patient ages ranged from 1-101 years (mean 53 years); a higher incidence was found for those aged 65 years. By age groups, there were more patients aged 61-80 years (575 patients). Most of the patients came to the hospital on their own initiative (1114) and 390 had been referred by their primary care physician. Renal colic (670 cases) was the most common diagnosis in both males and females, followed by cystitis, which was prevalent in the females (67.35%). Other conditions seen were urinary retention, hematuria, etc. CONCLUSIONS: There was a higher prevalence of males that consulted for urological conditions at the emergency department and there was a higher incidence in patients in the 6th and 7th decades of life, which is similar to the findings reported in other studies. Renal colic was the main reason for consultation for both genders and for all age groups, except those younger than 20 who presented more scrotal and penile involvement. Infective conditions involving the lower urinary tract (cystitis) and pyelonephritis were prevalent in the females. The large number of patients that were discharged from the emergency department and who consulted on their own initiative shows their confidence in the emergency services and that they could have been attended to at other health centers and did not have to come and unnecessarily strain the hospital emergency services.

Linfomas MALT CD5+ / CD5+ MALT lymphomas

Propósito: Los linfomas MALT son linfomas de bajo grado y se caracterizan por ausencia de expresión de CDS. No obstante, se han descrito algunos casos CD5 positivos. Material y métodos: Presentamos 6 linfomas MALT de bajo grado, 5 de estómago y uno de colon, CD5 positivos. Resultados: Los pacientes tenían una enfermedad localizada y no había invasión de médula ósea. El seguimiento medio fue de 12,6 meses. Concusiones: Nuestros casos demuestran que los linfomas MALT de bajo grado pueden presentar de forma atípica expresión de CD5 (AU)

[Expression of p53 in prostatic carcinoma]. / Expresión de p53 en carcinomas de próstata.

The expression of the p53 protein was studied in 10 men with prostate cancer by means of an immunohistochemical method. Strong staining for p53 was found in six of ten prostate cancer (60%, mean: 26% of malignant cells stained in the positive tumours). On the other hand, the cell nuclei in benign glands did not stain positively. Immunohistochemical pattern of p53 was not related significantly to clinicopathologic parameters in the cases examined. However, significant relationship was observed between prostate cancer stage D and stage B and mean of expression of p53 in both groups. Also, relationship between mean of expression of p53 of tumoral cells of grade IV and mean of expression of p53 of tumoral cells of grades I, II and III was observed.